Pharmacogenomics Analysis Laboratory

The Pharmacogenomics Analysis Laboratory (PAL) is a fully operational state-of-the-art research laboratory created to support pharmacogenomics and clinical trials within the Cooperative Studies program (CSP), Office of Research & Development, Veterans’ Affairs. PAL has partnered with CSP and VA investigators to determine genetic associations in diseases prevalent in veterans such as cardiovascular disease, neuropsychiatry, diabetes, oncology, HIV, and Amyotrophic Lateral Sclerosis.

* Please contact the Biomedical Research Foundation using our convenient Contact email form or call us at 501/257-4517 for PAL availability and pricing.

Technology

PAL is equipped to analyze moderate-to-large scale whole-genome methylation, genotyping, copy number variants, gene expression, and miRNA projects. The laboratory is equipped with a Life Technologies Personal Genome Sequencer and Ion Chef, Illumina MiSeq, Illumina Laboratory Information System (LIMS), Illumina iScan microarray system with an Autoloader 2, Sequenom MassARRAY system and NanoDispenser, an Illumina BeadXpress System, 3 Tecan Robots, an ABI TaqMan 7900 Real-Time PCR Instrument, NanoDrop Spectrophotometer, Biotek Synergy 4 Plate Reader, Beckman NXP Automated Liquid Handling Workstation, Agilent 2100 Bioanalyzer, Water purification systems, and miscellaneous laboratory equipment.

Applications using the Ion Torrent Personal Genome Sequencer and Illumina MiSeq include targeted re-sequencing, small RNA-Sequencing and Gene Expression profiling, ChIP-seq, whole-genome/exome validation, small genomes sequencing, copy number detection, paired-end sequencing, AmpliSeq Custom and Ready-to-use Gene Panels, and target capture. Two of the AmpliSeq Gene Panels include the Comprehensive Cancer Panel and the Inherited Disease Panel. Applications offered by the Illumina iScan system include whole-genome genotyping and CNV analysis, whole-genome gene expression and DNA methylation (450K targets), cytogenetic analysis and linkage profiling. Applications offered by the Sequenom Mass Spec include ADME panels, Sample Identity, Custom Genotyping.